Jennifer Esposito is currently married to Jesper Vesterstrøm; they have been together for three years since their wedding on September 13, 2020. Previously, Esposito was married to Louis Dowler from 2014 to 2016 and to Bradley Cooper from 2006 to 2007.

She was also engaged to Mark Philippoussis from 2009 to 2012. Esposito’s past relationships include Tony Daly (2004-2005), Benjamin Bratt (2001), Cameron Mathison (1999), Nick Chinlund (1997), Jonny Lee Miller, Gisele Bündchen (2004), and Dean Winters.